HUMAN URINE DECREASES FUNCTION AND EXPRESSION OF TYPE 1 PILI IN UROPATHOGENIC ESCHERICHIA COLI

ABSTRACT Uropathogenic Escherichia coli (UPEC) is the primary cause of community-acquired urinary tract infections (UTIs).UPEC bind the bladder using type 1 pili, encoded by the fim operon in nearly all E.coli.Assembled type 1 pili terminate in the FimH adhesin, which specifically binds to mannosylated glycoproteins on the bladder epithelium.Expres

Background: 3-Hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency is a rare inborn error of valine catabolism associated with progressive neurological impairment.This retrospective cohort study aimed to characterize kaiser copy stands the clinical, biochemical, genetic, and respiratory chain profiles of HIBCH deficiency patients in Bahrain.Methods: